苯并硫氮杂卓及其环加成产物的2D NMR 研究

苯并硫氮杂卓及其环加成产物的2D NMR 研究

崔育新, 刘晓峰, 吴海涛, 潘鑫复

1. 北京医科大学药学院, 天然药物及仿生药物国家重点实验室, 北京 100083
2. 兰州大学化学系, 兰州 730000

收稿日期:1997-12-12 修回日期:1998-06-16 出版日期:1998-12-15 发布日期:1998-12-15

2D NMR Studies on the Benzodiheteropine and its Cycloaddition Products

Yu-Xin Cui, Xiao-Feng Liu, Hai-Tao Wu, Xin-Fu Pan

1. National Research Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083
2. Department of Chemistry, Lanzhou University, Lanzhou 730000

Received:1997-12-12 Revised:1998-06-16 Online:1998-12-15 Published:1998-12-15

摘要/Abstract

摘要： 苯并硫氮杂卓是一类具有镇静作用的合成药物, 对精神病、心脏病及高血压等疾病有一定疗效。为了深入探讨其结构与药效关系, 应用¹H-¹H COSY, ¹³C-1H COSY和NOESY等2D NMR技术对苯并硫氮杂卓1及其环加成产物2~5进行了研究, 对其¹H、¹³C NMR化学位移进行了指定, 并分析讨论了化合物1~5的结构特征及苯并硫氮七元杂环呈船式构象的特点, 各相关质子间的偶合常数也与讨论结果相符。

关键词: 苯并杂卓, 二维核磁共振谱, 构象, 七元杂环

Abstract: The signals of ¹H NMR and ¹³C NMR for benzodiheteropine 1 and its cycloaddtion products 2~5 were assigned by two dimensional NMR techniques. The characteristics of their structures were analyzed and discussed. The boat conformation of the seven-membered heteroatomic ring in these structures was interpreted on the basis of the spectrum of NOESY as well. The coupling constants of relative protons were in accord with above results.

Key words: Benzodiheteropine, 2D NMR, Conformation, Seven membered heteroatomic ring

Supporting:

崔育新, 刘晓峰, 吴海涛, 潘鑫复. 苯并硫氮杂卓及其环加成产物的2D NMR 研究[J]. .

Yu-Xin Cui, Xiao-Feng Liu, Hai-Tao Wu, Xin-Fu Pan. 2D NMR Studies on the Benzodiheteropine and its Cycloaddition Products[J]. .

[1]	杨洪亮, 陈婷, 柏旭, 裴亚中^*. 激酶变构抑制剂: 一种新的高效和高选择性调节激酶活性的方式[J]. , 2012, 21(6): 531-543.
[2]	叶国柱, 张亮仁^*, 张礼和. 人血清白蛋白与硫代寡核苷酸的结合研究[J]. , 2007, 16(1): 9-13.
[3]	郝美荣, 杨铭^*. Ribavirin and DII-18-2与RNA的相互作用[J]. , 2001, 10(3): 124-127.
[4]	杨晓改, 李荣昌. 抗癌Pt(II)络合物与人红细胞收缩蛋白的相互作用[J]. , 1998, 7(3): 121-126.
[5]	郭宗儒, 刘全志, 王敏敏. 维甲类化合物构象的同效性研究[J]. , 1997, 6(4): 173-177.