盐酸奥丹西酮离子导入的研究

盐酸奥丹西酮离子导入的研究

丁平田, 李炜, 郑俊民

沈阳药科大学药剂教研室, 沈阳 110015

收稿日期:1997-09-09 修回日期:1998-03-16 出版日期:1999-06-15 发布日期:1999-06-15

Transdermal Iontophoretic Delivery of Ondansetron HCI

Ding Pingtian, Li Wei, Zheng Junmin

Department of Pharmaceutics, Shenyang Pharmaceutical University Shenyang 110015

Received:1997-09-09 Revised:1998-03-16 Online:1999-06-15 Published:1999-06-15

摘要/Abstract

摘要：

本文研究了奥丹西酮在不同电流密度下经小鼠全皮的渗透动力学。当电流密度从0.05 mA•cm^-2升高到0.3 mA•cm^-2时,药物的稳态流量从30.29 μg•cm^-2•h^-1增加到160.70 μg•cm^-2•h^-1。研究中药物稳态流量和应用电流之间不严格呈线性关系。铂在供药池中作阳极时,可导致药物溶液变色; 而应用银电极代替铂电极,则可以避免此问题的出现。应用铂电极时, 供药池和接受池中均发现有pH变化。文章对以上问题以及解决的方法进行了讨论。

关键词: 奥丹西酮, 经皮离子导入

Abstract:

The permeability of ondansetron at different current densities applied across the full-thickness mouse skin in vitro is reported. The steady state flux of ondansetron was increased from 30.29 μg·cm^-2·h^-1 to 160.70 μg.cm^-2·h^-1 When the current density changed from 0.05 mA·cm^-2 to 0.3 mA·cm^-2. But there was no strict linear relationship. Discoloration of ondansetron solution was found when platinum electrode was used in the donor compartment, which would be overcome by using Ag as electrode. The PH values in both donor and receptor compartments were changed in the study when platinum electrode was applied. The problems mentioned above and the keys to them were discussed.

Key words: Ondansetron, Transdermal iontophoretic delivery

Supporting:

丁平田, 李炜, 郑俊民

. 盐酸奥丹西酮离子导入的研究[J]. .

Ding Pingtian, Li Wei, Zheng Junmin. Transdermal Iontophoretic Delivery of Ondansetron HCI[J]. .