细胞透膜性肽以及其在外源性siRNA转运中的应用

摘要/Abstract

摘要： siRNA被认为是很有希望的基因治疗分子, 它通过介导靶mRNA降解而抑制基因表达。为了发挥siRNA分子的应用, 需要寻找适当的方法解决siRNA分子透膜性差的问题。用细胞透膜性肽进行药物细胞内转运是一种新的和充满希望的方法。本文将综述细胞透膜性肽在siRNA转运中的应用。初步研究表明这类转运载体具有较低的细胞毒性和较好的转运效率。

关键词: siRNA, 细胞透膜性肽, 转运

Abstract:

Given its ability to knock down essentially any gene of interest, siRNA has been one of the promising candidates for gene therapy. However, like other nucleic-acid-based drugs, its poor cellular uptake poses a major challenge. Here we briefly summarize the use of cell penetrating peptides (CPPs) as a novel and promising approach for siRNA delivery. The main advantages of CPPs are their low toxicity and high efficiency.

Key words:

siRNA,

siRNA, Cell penetrating peptides, Cell penetrating peptides, Delivery

, Delivery

中图分类号:

R916

Supporting:

^*Corresponding author. Ph.D., Professor of medicinal chemistry. Research interest is focused on chemical modified oligonucleotides and their biological activities.
Tel.: 86-10-82802503; e-mail: yangzj@bjmu.edu.cn

王晓锋, 刘洋, 王卓, 杨振军^*, 张礼和. 细胞透膜性肽以及其在外源性siRNA转运中的应用[J]. .

Xiao-Feng Wang, Yang Liu, Zhuo Wang, Zhen-Jun Yang^*, Li-He Zhang. Cell penetrating peptides and their applications in siRNA delivery[J]. .

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