血脂康用于治疗初期高脂血症

血脂康用于治疗初期高脂血症

寇文镕, 陆宗良, 郭静萱, 李海燕, 薛士文, 林玉珍, 吴学思, 陈红

1.北京阜外心血管病医院, 北京 100037;
2.北京医科大学第三临床医院;
3.中国人民解放军305医院;
4.北京安贞医院;
5.北京医科大学人民医院

收稿日期:2000-08-12 修回日期:2000-10-06 出版日期:2000-12-15 发布日期:2000-12-15

Xuezhikang in Treating Primary Hyperlipidemia

Kou Wenrong, Lu Zongliang, Guo Jingxuan, Li Haiyan, Xue Shiwen, Lin Yuzhen, Wu Xuesi, Chen Hong

1. Fuwai Hospital, CAMS and PUMC, Beijing 100037;
2. Third Affiliated Hospital, Beijing Medical University;
3. 305th Hospital, PLA;
4. Beijing Anzhen Hospital;
5. People's Hospital, Beijing Medical University

Received:2000-08-12 Revised:2000-10-06 Online:2000-12-15 Published:2000-12-15

摘要/Abstract

摘要： 目的: 比较血脂康和辛伐他汀用于治疗初期高脂血症的作用。方法: 108名患有初期脂血症的病人随机分为两组。第一组53名患者每日服4粒血脂康胶囊(1.2 g/天)共服八周; 第二组55名患者每日服辛伐他汀10 mg共服八周。八周后的血脂水平与各组的基线比较。结果: 第一组患者的血清总胆固醇(TC), 低密度脂蛋白(LDL)和甘油三酯(TG)分别降低23.0%, 28.0%和28.1%(P<0.001); 第二组分别降低23.3%, 29.5%和29.5%(P<0.001)。服药后血清高密度脂蛋白(HDL)胆固醇血脂康组升高5.0%(P>0.05)。辛伐他汀组升高14.3%(P<0.01)。两组间TC, LDL胆固醇, TG和HDL胆固醇的变化无显著性差异。血脂康的副作用比辛伐他汀的弱。结论: 中国产的血脂康为一种安全, 有效和耐受性良好的血脂调节剂。

关键词: 高脂血症, 血脂康, 辛伐他汀

Abstract: Objective: To compare the effects of Xuezhikang and Simvastain in patients with primary hyperlipidemia. Methods: One hundred eight patients with primary hyperlipidemia were randomly divided into two groups. Group 1, 53 patients, took 4 Xuezhikang capsules per day (1.2 g/d) for 8 weeks and Group 2, 55 patients took Simvastain 10 mg per day for 8 weeks. At the end of 8 weeks, the lipid levels were compared with those of the baseline in each group. Results: In Group 1, the serum levels of total cholesterol (TC), low-density lipoprotein (LDL) cholesterol and triglycerides (TG) decreased by 23.0%, 28.0% and 28.1% (P<0.001), and in Group 2 reduced by 23.3%, 29.5% and 29.5% (P<0.001) respectively. The serum levels of high-density lipoprotein (HDL) cholesterol after taking Xuezhikang increased by 5.0% (P>0.05) and after taking Simvastatin increased by 14.3% (P<0.01). No significant differences, however, were found between the two groups in TC, LDL cholesterol, TG and HDL cholesterol. The side effects of Xuezhikang were less than those of Simvastatin. Conclusion: Xuezhikang made in China is a safe, effective and well toleraled lipid modulator.

Key words: Hyperlipidemia, Hyperlipidemia, Xuezhikang, Xuezhikang, Simvastain, Simvastain

Supporting:

寇文镕, 陆宗良, 郭静萱, 李海燕, 薛士文, 林玉珍, 吴学思, 陈红. 血脂康用于治疗初期高脂血症[J]. .

Kou Wenrong, Lu Zongliang, Guo Jingxuan, Li Haiyan, Xue Shiwen, Lin Yuzhen, Wu Xuesi, Chen Hong . Xuezhikang in Treating Primary Hyperlipidemia[J]. .

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