蔓生百部中新生物碱的结构

蔓生百部中新生物碱的结构

邹长英^*, 李军, 雷海民, 付宏征, 林文翰

北京医科大学天然药物及仿生药物国家重点实验室, 北京 100083

收稿日期:1999-07-12 修回日期:2000-03-17 出版日期:2000-09-15 发布日期:2000-09-15
通讯作者: 邹长英*

A New Alkaloid from Root of Stemona japonica Miq

Zou Changying^*, Li Jun, Lei Haimin, Fu Hongzheng, Lin Wenhan

National Research Laboratories of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083

Received:1999-07-12 Revised:2000-03-17 Online:2000-09-15 Published:2000-09-15
Contact: Zou Changying*

摘要/Abstract

摘要： 从国产蔓生百部(Stemona japonica Miq.)的根部分得三种微量百部生物碱成份, 经波谱分析, 确定为脱氢百部碱(didehydrostemonine 1), 百部碱(stemonine 2), 脱氢原百部碱(didehydroprotostemonine 3)。其中脱氢百部碱为一新生物碱并首次归属了百部碱的波谱数据。

关键词: 蔓生百部, 脱氢百部碱, 波谱分析

Abstract: From the roots of Stemona japonica Miq., three stemona alkaloids, didehydrostemonine 1, ste-monine 2 and didehydroprotostemonine 3, were isolated by means of extensive Sil gel chromatographic separation. Their structures were identified by spectral analyses (IR, MS, ¹H, ¹³C NMR, ¹H-¹H COSY, NOESY, HMQC, HMBC) as well as 1H NMR line broadening effect. Compound 1 was a new stemona alkaloid, and 3 was a didehydroazaazu-lene alkaloid occurring in S. tuberosa, discovered in the roots of S. japonica firstly.

Key words: Stemona japonica Miq, Stemona japonica Miq, Didehydrostemonine, Didehydrostemonine, Spectral analysis, Spectral analysis

Supporting: ^*Current address: Shanxi Worker Medical College, Taiyuan.

邹长英^*, 李军, 雷海民, 付宏征, 林文翰. 蔓生百部中新生物碱的结构[J]. .

Zou Changying^*, Li Jun, Lei Haimin, Fu Hongzheng, Lin Wenhan. A New Alkaloid from Root of Stemona japonica Miq[J]. .