四苯硼钠法测定氯氮卓的含量

四苯硼钠法测定氯氮卓的含量

李彦威^*, 魏文珑, 王志忠, 王晋辉

1.太原理工大学化学工程与技术学院, 太原 030024;
2.山西大学校医院, 太原 030006

收稿日期:2002-06-04 修回日期:2002-09-15 出版日期:2002-12-15 发布日期:2002-12-15
通讯作者: 李彦威*

Determination of Chlordiazepoxide by Sodium Tetraphenylboron Method

Li Yanwei^*, Wei Wenlong, Wang Zhizhong, Wang Jinhui

1.College of Chemical Engineering and Technology, Taiyuan University of Technology, Taiyuan 030024;
2.Hospital of Shanxi University, Taiyuan 030006

Received:2002-06-04 Revised:2002-09-15 Online:2002-12-15 Published:2002-12-15
Contact: Li Yanwei*

摘要/Abstract

摘要： 本文介绍一种可有效地测定氯氮卓含量的方法。在pH = 4 .0的HAc-NaAc缓冲溶液中, 加入过量的四苯硼钠与氯氮卓反应可形成分子比为1:1的定量沉淀, 过滤, 弃去初滤液。以溴酚蓝为指示剂, 用十六烷基三甲基溴化铵标准溶液滴定续滤液中过量的四苯硼钠, 方法简便快速, 应用于多批氯氮卓原料药样品的测定, 其回收率为99.58%~100.4% , 相对误差<±0.50%, 与中国药典法测得的结果基本一致。

关键词: 氯氮卓, 四苯硼钠, 溴酚蓝, 十六烷基三甲基溴化铵

Abstract: This paper describes an effective method for determining chlordiazepoxide. An excess of sodium tetraphenylboron is added to precipitate chlordiazepoxide in HAc-NaAc buffer solution (pH = 4.0). After filtering off the precipitate, the excessive sodium tetraphenylboron in the filtrate is titrated with cetyltrimethylammonium bromide standard solution, with bromophenol blue as indicator. The method is simple and rapid, it has been applied for the determination of chlordiazepoxide raw materials with satisfactory results. The recovery is between 99.58% and 100.4%, the relative error is less than ±0.50%. Experiments show that the method gives the same results as the approach using nonaqueous titration (ChP).

Key words: Chlordiazepoxide, Chlordiazepoxide, Sodium tetraphenylboron, Sodium tetraphenylboron, Bromophenol blue, Bromophenol blue, Cetyltrimethylammonium bromide, Cetyltrimethylammonium bromide

Supporting:

李彦威^*, 魏文珑, 王志忠, 王晋辉. 四苯硼钠法测定氯氮卓的含量[J]. .

Li Yanwei^*, Wei Wenlong, Wang Zhizhong, Wang Jinhui . Determination of Chlordiazepoxide by Sodium Tetraphenylboron Method[J]. .

[1]	赵彦生, 李彦威^*, 魏文珑, 王晋辉. 四苯硼钠法测定乳酸环丙沙星的含量[J]. , 2002, 11(1): 24-27.
[2]	李彦威, 赵彦生, 宣春生, 魏文珑. 2,4-二硝基苯酚荷移分光光度法测定氯氮卓的含量[J]. , 2001, 10(4): 196-199.