pH对盐酸美普他酚鼻腔吸收的影响

pH对盐酸美普他酚鼻腔吸收的影响

史振祺, 蒋新国^*

复旦大学药学院药剂学教研室, 上海 200032

收稿日期:2003-10-12 修回日期:2004-02-10 出版日期:2004-03-15 发布日期:2004-03-15
通讯作者: 蒋新国*

Influence of pH Environment on Nasal Absorption of Meptazinol Hydrochloride

SHI Zhen-qi, JIANG Xin-guo^*

Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China

Received:2003-10-12 Revised:2004-02-10 Online:2004-03-15 Published:2004-03-15
Contact: JIANG Xin-guo*

摘要/Abstract

摘要： 目的　研究盐酸美普他酚制剂中pH和鼻腔吸收之间的关系。方法　通过鼻腔在体循环试验考察不同pH环境对盐酸美普他酚鼻腔吸收的影响, 并利用体内试验考察模型药物经鼻入脑的情况。结果　鼻腔在体循环试验发现盐酸美普他酚在碱性条件下吸收显著优于酸性条件, 但是在体内试验中发现不同pH环境对药物吸收入脑并没有显著性差异。结论　制剂中的pH环境对盐酸美普他酚鼻腔吸收和入脑无显著影响。

关键词: 鼻腔吸收, 鼻腔吸收, pH环境, pH环境, 亲脂性药物, 亲脂性药物, 盐酸美普他酚, 盐酸美普他酚

Abstract: Aim To investigate the relationship between pH environment of meptazinol hydrochloride (MEP) and its nasal absorption. Methods In situ nasal perfusion was performed to study the effect of pH environment on the nasal absorption. Its effect on the transport from nose to brain was further researched by in vivo experiment. Results In in situ perfusion experiment, the nasal absorption of MEP in basic environment was significantly higher than that in acid condition, but the difference was not observed in in vivo experiment. Conclusion The pH environment of meptazinol hydrocloride in formulation cannot be regarded as an important factor influencing nasal absorption and transport from nose to brain.

Key words: nasal absorption, nasal absorption, pH environment, pH environment, lipophilic drug, lipophilic drug, meptazinol hydrochloride, meptazinol hydrochloride

中图分类号:

R944.7

R965.3

Supporting: Foundation item: National Natural Science Foundation of China (30171112).
^*Corresponding author. Tel.: 021-5423-7381; fax: 021-5423-7381

史振祺, 蒋新国^*

. pH对盐酸美普他酚鼻腔吸收的影响[J]. .

SHI Zhen-qi, JIANG Xin-guo^*. Influence of pH Environment on Nasal Absorption of Meptazinol Hydrochloride[J]. .