张礼和, 在药学路上前行

中国药学(英文版)

张礼和, 在药学路上前行

付冬红, 武慧媛, 宋书香

收稿日期:2014-03-01 修回日期:2014-03-10 出版日期:2014-03-13 发布日期:2014-03-15

Lihe Zhang, travels on the pharmaceutical road

Donghong Fu, Huiyuan Wu, Shuxiang song

Received:2014-03-01 Revised:2014-03-10 Online:2014-03-13 Published:2014-03-15

摘要/Abstract

摘要：

“老师不仅要传授知识而且也要在自己工作的领域中进行创新性的研究, 追踪学科发展的前沿, 这样才能在给学生传授知识的同时, 告诉学生如何去掌握开启知识宝库大门的钥匙。当今的世界知识创新成为国家竞争力的核心要素, 高校的责任就是要为国家培养高质量的创新型人才, 同时也要做出创新性的研究成果, 为国民经济的发展做出贡献。”
著名药物化学家、中国科学院院士、北京大学药学院张礼和教授在2012年9月6日北京市委、市政府召开教师节庆祝大会上, 作为有“献身教育事业并做出突出贡献的优秀教师”代表发言, 这其中的两段话, 浓缩了他半个多世纪如何为师, 如何在科研领域攀登的人生路。张礼和教授, 长期从事核酸化学及抗肿瘤抗病毒药物研究, 系统研究了细胞内环核苷酸类 (c-AMP和c-ADPR) 信使分子的构效关系, 对酶性核酸断裂RNA机理以及结构修饰的寡核苷酸对核酸序列识别、稳定性和酶诱导活性进行了研究。多次获得国内外重要科技奖项, 2013年获得北大教师最高荣誉奖 “蔡元培奖”。

Abstract:

Professor Lihe Zhang, Academician of the Chinese Academy, is the founder and research leader on nucleosides and nucleotides, and also a worldwide famous pharmaceutical chemist. Firstly, he served at School of Pharmaceutical Sciences, Peking University Health Science Center as Assistant and Lecturer. From 1981 to 1983, he worked as Research Associate in Department of Chemistry, University of Virginia, USA. Since 1985 he has become a professor and then was designated as Dean of School of Pharmaceutical Sciences, Director of Chemistry Department, National Natural Science Foundation of China, and Director of State Key Laboratory of Natural and Biomimetic Drugs, Peking University.
His research interests include Cyclic ADP-ribose (cADPR), a metabolite of NAD+, which is a signaling molecule to regulate calcium mobilization via ryanodine receptors (RyR) from intracellular stores in a wide variety of biological systems. A main approach to explore the molecular mechanism of calcium release is to investigate the relationship of the structure of cADPR and cADPR analogues with their respective biological activities. In addition to the structure activity relationship, such studies result in novel antagonists and agonists which serve as the tools for mechanistic studies in the complex cellular system or potential drug lead. This publication list contains more than 200 original research articles and review papers. For his outstanding works, a serial prizes was awarded to him, such as: National Natural Science Award, Second Prize, Ministry of Science and Technology, China; Millennium Pharmaceutical Scientist Award, FIP, San Francisco, USA; Nagai-Hisamitsu Outstanding Science Award, Asia Pharmaceutical Association, Kyoto, Japan and so on.

Supporting:

付冬红, 武慧媛, 宋书香. 张礼和, 在药学路上前行[J]. 中国药学(英文版).

Donghong Fu, Huiyuan Wu, Shuxiang song. Lihe Zhang, travels on the pharmaceutical road[J]. Journal of Chinese Pharmaceutical Sciences.