Liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method for quantitative estimation of moxifloxacin in human plasma

doi:10.5246/jcps.2014.03.020

中国药学(英文版)

Liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method for quantitative estimation of moxifloxacin in human plasma

Vipul. M. Vaghela, Prajesh Prajapati*, Hetal K. Patel

1. Shree Swaminarayan Sanskar Pharmacy College, Zundal-382421, Gujarat, India
2. A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, Vallabh Vidhyanagar-388120, Gujarat, India
3. Institute of Research and Development, Gujarat Forensic Sciences University, Gandhinagar-382007, Gujarat, India

收稿日期:2013-10-07 修回日期:2013-10-29 出版日期:2014-03-13 发布日期:2013-11-07
通讯作者: *Corresponding author. Tel.: +91-9825318996; Fax: 07923247465; E-mail: prajeshprajapati@gmail.com
作者简介:*Corresponding author. Tel.: +91-9825318996; Fax: 07923247465; E-mail: prajeshprajapati@gmail.com

Liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method for quantitative estimation of moxifloxacin in human plasma

Vipul. M. Vaghela, Prajesh Prajapati*, Hetal K. Patel

1. Shree Swaminarayan Sanskar Pharmacy College, Zundal-382421, Gujarat, India
2. A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, Vallabh Vidhyanagar-388120, Gujarat, India
3. Institute of Research and Development, Gujarat Forensic Sciences University, Gandhinagar-382007, Gujarat, India

Received:2013-10-07 Revised:2013-10-29 Online:2014-03-13 Published:2013-11-07
Contact: *Corresponding author. Tel.: +91-9825318996; Fax: 07923247465; E-mail: prajeshprajapati@gmail.com
About author:*Corresponding author. Tel.: +91-9825318996; Fax: 07923247465; E-mail: prajeshprajapati@gmail.com

摘要/Abstract

摘要：

A rapid and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of moxifloxacin (MOXI) in human plasma. After a simple protein precipitation using acetonitrile, the post treatment samples were analysed on a C₁₈ column interfaced with a Triple Quadropole Tandem Mass Spectrometer. Positive electrosprayionization was employed as the ionization source. The mobile phase consisted of 0.1% formic acid–acetonitrile (60:40, v/v). Ciprofloxacin (CIPRO) was used as an internal standard. The analyte and internal standard (CIPRO) were monitored in the multiple reaction monitoring mode (MRM). The mass transition ion-pair has been followed as m/z 402→358.2 for MOXI and 332→288.1 for CIPRO. The method was linear in the concentration range of 25–5000 ng/mL. The lower limit of quantification was 25 ng/mL. The intra- and inter-day precision (relative standard deviation) and accuracy (relative error) values were within 12.4%. Each plasma sample was analyzed within 3 min.

关键词: Moxifloxacin, Ciprofloxacin, Human plasma, Liquid chromatography tandem mass spectrometry, Electrospray ionization

Abstract:

Key words: Moxifloxacin, Ciprofloxacin, Human plasma, Liquid chromatography tandem mass spectrometry, Electrospray ionization

中图分类号:

R917

Supporting:

Vipul. M. Vaghela, Prajesh Prajapati, Hetal K. Patel. Liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method for quantitative estimation of moxifloxacin in human plasma[J]. 中国药学(英文版), DOI: 10.5246/jcps.2014.03.020.

Vipul. M. Vaghela, Prajesh Prajapati, Hetal K. Patel. Liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method for quantitative estimation of moxifloxacin in human plasma[J]. Journal of Chinese Pharmaceutical Sciences, DOI: 10.5246/jcps.2014.03.020.

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Liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method for quantitative estimation of moxifloxacin in human plasma

Liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) method for quantitative estimation of moxifloxacin in human plasma

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