异核苷掺入和肽缀合修饰的寡核苷酸

doi:10.5246/jcps.2012.06.065

异核苷掺入和肽缀合修饰的寡核苷酸

黄野, 王晓锋, 杨振军^*, 张礼和

北京大学医学部天然药物及仿生药物国家重点实验室, 北京 100191

收稿日期:2012-07-16 修回日期:2012-09-16 出版日期:2012-10-25 发布日期:2012-10-25
通讯作者: 杨振军*

Modification of oligonucleotides by isonucleosides incorporation and peptides conjugation

Ye Huang, Xiaofeng Wang, Zhenjun Yang^*, Lihe Zhang

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2012-07-16 Revised:2012-09-16 Online:2012-10-25 Published:2012-10-25
Contact: Zhenjun Yang*

摘要/Abstract

摘要：

人工合成的寡核苷酸, 包括反义寡核苷酸、干扰RNA等, 显示了优异的临床潜在应用价值。但要实现合成的寡核苷酸的广泛临床应用, 必须要克服一些障碍性问题, 如该类结构的不稳定性、非特异性作用及难以跨膜吸收等。本文综述了张礼和院士课题组在异核苷掺入及肽缀合寡核苷酸方面的研究成果。

关键词: 人工合成寡核苷酸, 异核苷, 透膜肽, 干扰RNA

Abstract:

Synthetic oligonucleotides including antisense oligonucleotides and siRNA have shown promising therapeutic potential. However, to realize the therapeutic potential of synthetic oligonucleotides, many obstacles have to be overcome, such as their poor biological stability, non-specific activity and inadequate cell membrane permeability. In this paper, the achievements by Lihe Zhang's group in the study of isonucleotide modified oligonucleotides and oligonucleotides conjugated with cell penetrating peptides are summarized.

Key words: Synthetic oligonucleotide, Isonucleoside, Cell penetrating peptide, siRNA

中图分类号:

R916.1

Supporting: Foundation items: National Natural Science Foundation (Grant No. 20932001), the Ministry of Science and Technology (Grant No. 2012CB720604).
^*Corresponding author. Tel.: 86-10-82802503; E-mail: yangzj@bjmu.edu.cn
Dedicated to Professor Lihe Zhang on the occasion of his 75^th birthday.

黄野, 王晓锋, 杨振军^*, 张礼和. 异核苷掺入和肽缀合修饰的寡核苷酸[J]. , DOI: 10.5246/jcps.2012.06.065.

Ye Huang, Xiaofeng Wang, Zhenjun Yang^*, Lihe Zhang . Modification of oligonucleotides by isonucleosides incorporation and peptides conjugation[J]. , DOI: 10.5246/jcps.2012.06.065.

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