Polymorphisms in ghrelin and heparan sulfate proteoglycan genes and their association with diabetic nephropathy in Pakistani population

doi:10.5246/jcps.2012.03.033

Polymorphisms in ghrelin and heparan sulfate proteoglycan genes and their association with diabetic nephropathy in Pakistani population

Khuram Shehzad, Maria Rasool, Mahjabeen Saleem^*, Mamoona Naz

Institute of Biochemistry and Biotechnology, University of the Punjab, Lahore 54590, Pakistan

收稿日期:2011-12-30 修回日期:2012-03-15 出版日期:2012-05-15 发布日期:2012-05-15
通讯作者: Mahjabeen Saleem*

Polymorphisms in ghrelin and heparan sulfate proteoglycan genes and their association with diabetic nephropathy in Pakistani population

Khuram Shehzad, Maria Rasool, Mahjabeen Saleem^*, Mamoona Naz

Institute of Biochemistry and Biotechnology, University of the Punjab, Lahore 54590, Pakistan

Received:2011-12-30 Revised:2012-03-15 Online:2012-05-15 Published:2012-05-15
Contact: Mahjabeen Saleem*

摘要/Abstract

摘要：

Diabetic nephropathy (DN), a long term complication of diabetes, is the most common cause of end-stage renal disease, increasing the risk of death. Genetic predispositions play an important role in determining the susceptibility of the development of DN. Heparan sulphate proteoglycan (HSPG) and ghrelin (GH) gene polymorphisms are associated with the risk of DN. T allele frequency of the HSPG gene determined by BamHI polymorphism located in intron 6 may be a risk factor for the development of renal dysfunction in DN (Fisher two tailed test, CI = 95%, d.f. = 29, P = 0.016). The ghrelin gene polymorphism is caused by a cytosine-to-adenine transition in exon 2 of the preproghrelin gene forming Leu72Met variant. In Pakistani population, the preproghrelin Leu72Met polymorphism was observed to be not associated with diabetic nephropathy in patients as indicated by statistical analysis (CI = 95%, d.f. = 29, P = 0.691). The allelic frequencies of HSPG genetic polymorphism has the potential to be used as diagnostic markers for diabetic nephropathy disease.

关键词: Diabetic nephropathy, Ghrelin, Heparan sulfate proteoglycan polymorphism, Type 2 diabetes mellitus

Abstract:

Key words: Diabetic nephropathy, Ghrelin, Heparan sulfate proteoglycan polymorphism, Type 2 diabetes mellitus

中图分类号:

R963

Supporting: *Corresponding author. Tel.: 97-42-9230355

Khuram Shehzad, Maria Rasool, Mahjabeen Saleem^*, Mamoona Naz . Polymorphisms in ghrelin and heparan sulfate proteoglycan genes and their association with diabetic nephropathy in Pakistani population[J]. , DOI: 10.5246/jcps.2012.03.033.

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Polymorphisms in ghrelin and heparan sulfate proteoglycan genes and their association with diabetic nephropathy in Pakistani population

Polymorphisms in ghrelin and heparan sulfate proteoglycan genes and their association with diabetic nephropathy in Pakistani population

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