多巯基功能性保护氨基酸的合成

doi:10.5246/jcps.2011.02.025

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多巯基功能性保护氨基酸的合成

杨颖, 王超^*

北京大学医学部药学院药物化学系, 北京 100191

收稿日期:2010-11-07 修回日期:2011-01-05 出版日期:2011-03-15 发布日期:2011-03-15
通讯作者: 王超*

Synthesis of functional amino acids bearing 1,3-dithiane modification

Ying Yang, Chao Wang^*

Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2010-11-07 Revised:2011-01-05 Online:2011-03-15 Published:2011-03-15
Contact: Chao Wang*

摘要/Abstract

摘要：

本文通过直接还原N-烷基化的反应将1,3-二噻烷衍生物导入赖氨酸侧链, 合成了两个保护的氨基酸络合剂N^α-Fmoc-Nε, Nε-di((2,2-dimethyl-1, 3-dithian-5-yl)methyl)-L-lysine (7) 及N^α-Fmoc-N^ε-(2,2-dimethyl-1,3-dithian-5-yl)methyl, N^ε-Boc-L-lysine (9)。此保护氨基酸将在多肽化学应用中发挥作用。

关键词: 氨基酸络合剂, 1,3-二噻烷衍生物, 还原N-烷基化反应

Abstract:

Two protected single amino acid chelates, N^α-Fmoc-N^ε, N^ε-di((2,2-dimethyl-1, 3-dithian-5-yl)methyl)-L-lysine (7) and N^α-Fmoc-N^ε-(2,2-dimethyl-1,3-dithian-5-yl)methyl, N^ε-Boc-L-lysine (9), were synthesized by modifying the side chain of lysine with 1,3-dithiane through direct reductive N-alkylation protocol. These amino acids have potential uses in peptide chemistry.

Key words: Amino acid chelate, 1,3-Dithiane, Reductive N-alkylation

中图分类号:

R916

Supporting:

^*Corresponding author. Tel.: 86-10-82805049

杨颖, 王超^*. 多巯基功能性保护氨基酸的合成[J]. , DOI: 10.5246/jcps.2011.02.025.

Ying Yang, Chao Wang^*. Synthesis of functional amino acids bearing 1,3-dithiane modification [J]. , DOI: 10.5246/jcps.2011.02.025.

多巯基功能性保护氨基酸的合成

Synthesis of functional amino acids bearing 1,3-dithiane modification

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