响应面法优化超临界CO2萃取淫羊藿苷的工艺研究

doi:10.5246/jcps.2011.02.020

响应面法优化超临界CO₂萃取淫羊藿苷的工艺研究

关雅琼, 张曜武^*, 张龙

青岛科技大学化工学院药学系, 山东青岛 266042

收稿日期:2010-12-03 修回日期:2011-02-10 出版日期:2011-03-15 发布日期:2011-03-15
通讯作者: 张曜武*

Optimization for supercritical CO₂ extraction of icariin by response surface method

Ya-Qiong Guan, Yao-Wu Zhang^*, Long Zhang

Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Received:2010-12-03 Revised:2011-02-10 Online:2011-03-15 Published:2011-03-15
Contact: Yao-Wu Zhang*

摘要/Abstract

摘要：

利用星点设计–响应面法对淫羊藿中淫羊藿苷的超临界萃取工艺进行优化。根据星点设计原理采用3因素5水平的响应面分析法, 以提取温度、提取压力、夹带剂流速为自变量, 淫羊藿苷得率为因变量, 通过对自变量各水平的多元线性回归及二项式拟合, 选取超临界CO2 提取淫羊藿苷最优工艺为超临界提取温度46.5 ºC、提取压力30.6 MPa、夹带剂流速3.3 mL/min。星点设计–响应面法优选淫羊藿中的淫羊藿苷提取工艺, 方法简便, 预测性良好。

关键词: 响应面法, 星点设计, 超临界萃取, 淫羊藿, 淫羊藿苷

Abstract:

The aim of the present study was to optimize the supercritical CO2 extraction conditions of icariin from Herba Epimedii by response surface method (RSM) and central composite design (CCD). A 3-factor, 5-level CCD was used for the optimization. Independent variables were extraction temperature, extraction pressure and entrainer flow rate. Dependent variable was yield ratio of icariin from Herba Epimedii. A two-order polynomial equation was fitted to the data. The results showed that the optimum extraction conditions were as follows: extraction temperature 46.5 ºC, extraction pressure 30.6 MPa, entrainer flow rate 3.3 mL/min. CCD/ RSM is convenient and highly predictive for optimizing the extraction process of icariin from Herba Epimedii.

Key words: Response surface method, Central composite design, Supercritical fluid extraction, Herba Epimedii, Icariin

中图分类号:

R284

Supporting:

^*Corresponding author. Tel.: 86-532-84023884

关雅琼, 张曜武^*, 张龙. 响应面法优化超临界CO₂萃取淫羊藿苷的工艺研究[J]. , DOI: 10.5246/jcps.2011.02.020.

Ya-Qiong Guan, Yao-Wu Zhang^*, Long Zhang . Optimization for supercritical CO₂ extraction of icariin by response surface method [J]. , DOI: 10.5246/jcps.2011.02.020.

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响应面法优化超临界CO₂萃取淫羊藿苷的工艺研究

Optimization for supercritical CO₂ extraction of icariin by response surface method

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