Research progress on the non-coding region of single-stranded positive-sense RNA (+ssRNA) viruses

doi:10.5246/jcps.2025.01.001

Abstract

Abstract:

Single-stranded positive-sense RNA (+ssRNA) viruses encompass a diverse range of species and exert profound effects on human and animal health, as well as agricultural economic productivity. The 5ʹ and 3ʹ untranslated regions (UTRs) of these viruses play pivotal roles in regulating critical processes such as translation initiation, RNA synthesis, virus assembly, and virulence. This article provided an overview of the untranslated regions in representative species of single-stranded positive-sense RNA (+ssRNA) viruses, highlighting their potential in vaccine development research and addressing some of the challenges currently faced in this field.

Key words: +ssRNA virus, UTR, Structure, Vaccine

Supporting:

Liangrong Guo, Guoyue Liu, Ju Sun, Dengguo Wei. Research progress on the non-coding region of single-stranded positive-sense RNA (+ssRNA) viruses[J]. Journal of Chinese Pharmaceutical Sciences, 2025, 34(1): 1-13.

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