Continuous-flow, one-pot synthesis of asymmetrical aromatic ureas from acids and amines via curtius rearrangement

doi:10.5246/jcps.2022.12.079

Abstract

Supporting:

Meng Tong, Wei Zhan, Chengcheng Niu, Zemei Ge, Runtao Li, Xin Wang. Continuous-flow, one-pot synthesis of asymmetrical aromatic ureas from acids and amines via curtius rearrangement[J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(12): 938-945.

Figures/Tables 6

Table 1. Optimization of the reaction for one-pot synthesis of ureas in continuous-flow microreactora.

Table 2. Substrate scope of different acid under optimized conditionsa.

Table 3. Substrate scope of different amide under optimized conditionsa.

References 35

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