Biological investigation of phenyl benzoate, benzophenone, and xanthone compounds

doi:10.5246/jcps.2022.10.063

Abstract

Abstract:

In the present study, we evaluated the antitumor, anti-tyrosinase, anti-pancreatic lipase, antibacterial, antifungal, and anti-α‐glycosidase activities for all or a subset of 20 known compounds. They included 8 phenyl benzoates, 10 benzophenones, and 2 xanthones. Phenyl benzoate compounds 1–8 did not exhibit evident antitumor activity, which was consistent with existing theories. Compounds 16, 17, and 18 exhibited moderate anti-tyrosinase activity. In addition, compounds 11 and 18 exhibited moderate inhibitory activity against Candida albicans, and compound 20 exhibited stronger anti-α-glycosidase activity than quercetin, with an IC₅₀ of approximately 2.45 μM. These results demonstrated that compounds 11, 16–18, and 20 were promising leads for further structural modification.

Key words: Phenyl benzoate, Benzophenone, Xanthone, Antibacterial, Antifungal, α-Glycosidase

Supporting:

Beidou Zhou, Chun Lei, Xuemei Liao, Hang Zhu, Zhipeng Ruan, Yuanyuan Fang, Guifen Xu, Yuli Chen. Biological investigation of phenyl benzoate, benzophenone, and xanthone compounds[J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(10): 738-745.

Figures/Tables 11

Table 1. The inhibitory activities of compounds 1–8 at 40 μM against five cancer cell lines.

Table 2. Anti-tyrosinase activities of compounds 12–20.

Table 3. Anti-pancreatic lipase activities of compounds 9–13 and 16–19.

Table 4. The inhibitory activities of compounds 9–11 and 14–20 against four bacterial strains.

Table 5. The MIC50 values of compounds 11, 16–18, and 20 against S. aureus.

Table 6. The inhibitory activities of compounds 9–11 and 14–20 against Candida albicans.

Table 7. The inhibitory activities of compounds 16–20 against α-glycosidase.

Table 8. The IC50 values of compounds 16, 18, and 20 against α-glycosidase.

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