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Journal of Chinese Pharmaceutical Sciences ›› 2022, Vol. 31 ›› Issue (6): 461-470.DOI: 10.5246/jcps.2022.06.040

• Original articles • Previous Articles     Next Articles

Solubility enhancement of ethyl p-methoxycinnamate under nanoscale confinement

Revika Rachmaniar1,2,4,5, Dolih Gozali1,2, Camellia Panatarani3,4, Wahyu Priyo Legowo5, Sohadi Warya5, Taofik Rusdiana1,2,*()   

  1. 1 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Jatinangor 45363, West Java, Indonesia
    2 Pharmaceutical Development Study Centre, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Jatinangor 45363, West Java, Indonesia
    3 Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Jatinangor 45363, West Java, Indonesia
    4 Functional Nano Powder, University Center of Excellence, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Jatinangor 45363, West Java, Indonesia
    5 Department of Pharmaceutics, Indonesian School of Pharmacy, Jl. Soekarno-Hatta No. 354, Bandung 40266, West Java, Indonesia
  • Received:2022-01-13 Revised:2022-02-14 Accepted:2022-03-11 Online:2022-06-30 Published:2022-06-30
  • Contact: Taofik Rusdiana

Abstract:

The low solubility of ethyl p-methoxycinnamate (EPMC) inhibits its absorption in the gastrointestinal tract, impairing its pharmacological effect. The solubility of EPMC can be increased by utilizing a carrier in the type of mesoporous silica nanoparticles (MSN). In the present study, we aimed to confine EPMC under the nanoscale of MSN (MSN-EPMC) to increase the water solubility of EPMC. MSN was prepared using sodium silica as a precursor and Tween 80 and Span 80 as templates. Briefly, 500 mg MSN was dispersed into 2% w/v EPMC solution, stirred at 100 r/min for 24 h, and dried at 60 °C. The results showed that the MSN formed had a particle size of 87.1305 nm, a surface area of 68.86 m2/g, a pore diameter of 20.45 nm, and a pore volume of 0.352 cm3/g. EPMC was successfully confined under the nanoscale of MSN. MSN-EPMC had an amorphous structure, a loading capacity of 10.6%, and a loading efficiency of 18.18%. The solubility of MSN-EPMC was increased by 2.63 folds at 30 min compared with EPMC. The amorphous structure of MSN-EPMC was responsible for the enhancement of the water solubility. It could be concluded that the confining of EPMC in MSN had the potential to increase the solubility of a water-soluble isolate of a plant.

Key words: Solubility, Ethyl p-methoxycinnamate, Mesoporous silica nanoparticles

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