Synthesis of Hydroxyethylene-based β-Secretase Inhibitors

Abstract

Abstract: Aim To discuss in depth the synthesis of hydroxyethylene dipeptide-based β-secretase inhibitors; Methods Organic reactions such as nucleophilic addition and substitution assisted by organometallic agents, catalytic hydrogenation, and classic peptide coupling were used to synthesize peptidomimetic β-secretase inhibitors. Results Ideal reaction conditions and potential problems were investigated, and one of the designed β-secretase inhibitors 13 (as a model) was synthesized successfully; Conclusion This approach might be used to build up the β-secretase inhibitor library and to search for new molecular candidates.

Key words: β-secretase, β-secretase, peptidomimetics, peptidomimetics, hydroxyethylene dipeptide isostere, hydroxyethylene dipeptide isostere, synthesis, synthesis

CLC Number:

R916

Supporting:

YANG Xiao-ming, ZOU Xiao-min, FU Yi-qiu, MOU Ke, XU Ping^*. Synthesis of Hydroxyethylene-based β-Secretase Inhibitors[J]. .

References

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