Chemical constituents from Xiaoaiping injection

doi:10.5246/jcps.2014.04.035

Journal of Chinese Pharmaceutical Sciences ›› 2014, Vol. 23 ›› Issue (4): 251-255.DOI: 10.5246/jcps.2014.04.035

• Original articles • Previous Articles Next Articles

Chemical constituents from Xiaoaiping injection

Yirun Wang, Mingbo Zhao, Li Tang, Pengfei Tu^*

1. College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China
2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2014-01-13 Revised:2014-02-11 Online:2014-04-28 Published:2014-02-20
Contact: *Corresponding author. Tel.: 86-10-82802750; E-mail: pengfeitu@bjmu.edu.cn
About author:*Corresponding author. Tel.: 86-10-82802750; E-mail: pengfeitu@bjmu.edu.cn

Abstract

Abstract:

Xiaoaiping injection is a single-prescription of Marsdenia tenacissima. One newcompound, tenacigenoside L(1), along with ten known compounds were isolated from the CHCl₃-soluble fraction of Xiaoaiping injection extractby silica gel, ODS, Sephadex LH-20 and semi-preparative HPLC chromatography. The new compound was characterized as 3-O-β-D-oleandropyranosyl-17β-tenacigenin B. The ten known compounds were identified as tenacigenin B (2), 17β-tenacigenin B (3), marsdenoside F (4), tenacissoside G (5),tenacissoside I(6), tenacissoside H (7), marsdenoside D(8), tenacigenin A (9), marsdenoside I (10), and tenacigenin C (11). The structures of 11 compounds were elucidated on the basis of extensive analyses of spectroscopic data including MS, 1D NMR and 2D NMR, and comparison of their spectroscopic data with those reported in the literatures.

Key words: Xiaoaiping injection, Marsdenia tenacissima, Polyoxypregnane glycoside

CLC Number:

R284

Supporting:

Yirun Wang, Mingbo Zhao, Li Tang, Pengfei Tu. Chemical constituents from Xiaoaiping injection[J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(4): 251-255.

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Chemical constituents from Xiaoaiping injection

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