Anti-neuroinflammatory constituents from Artemisia argyi

doi:10.5246/jcps.2013.04.055

Abstract

Abstract:

Chemical constituents of the leaves of Artemisia argyi were investigated. By using a variety of chromatographic techniques and spectroscopic methods, six compounds were isolated and identified as follows: clemaphenol A (1), aurantiamide acetate (2), camelliagenin A (3), japonica acid (4), labd-13(E)-ene-8α,15-diol (5), and 3β-acetoxy-20-oxo-21-nordammaran-23-oic acid (6). Among these products, compounds 1 and 3-6 were obtained from the genus Artemisia for the first time and compound 2 was firstly reported from the species. Additionally, compound 5 displayed an inhibitory effect against the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells with an IC50 value of 6.68 μM.

Key words: Artemisia argyi, Asteraceae, Chemical constituents, Anti-neuroinflammatory

CLC Number:

R284

Supporting:

Shu Wang, Yong Jiang, Kewu Zeng, Jingrong Cui, Pengfei Tu^* . Anti-neuroinflammatory constituents from Artemisia argyi[J]. , DOI: 10.5246/jcps.2013.04.055.

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