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Synthesis and evaluation of tetrahydro β-carboline derivatives as anticancer agents

Hongrui Liu, Guangzhi Bao, Suna Yang, Lixin Wu, Xianfeng Gu*, Yizhun Zhu*   

  1. 1. Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China
    2. Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China
  • Received:2012-04-05 Revised:2012-06-25 Online:2012-09-15 Published:2012-09-15
  • Contact: Xianfeng Gu*, Yizhun Zhu*

Abstract:

A series of β-carboline derivatives (1-6) have been synthesized and evaluated for their anticancer activities. We observed that compound 5 exhibited significant anticancer activities over both human gastric cancer and human hepatic cancer cell lines, and compound 6, which is slightly different from 5 in its structure, showed good anticancer activity over human colorectal cancer cell line.

Key words: Indole, Tetrahydro β-carboline, Anticancer

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