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Improved synthesis of leonurine as cardioprotective agent

Shan-Shan Luo, Xian-Feng Gu*, Yi-Zhun Zhu*   

  1. School of Pharmacy, Fudan University, Shanghai 200032, China
  • Received:2012-02-24 Revised:2012-05-20 Online:2012-06-25 Published:2012-06-25
  • Contact: Xian-Feng Gu*, Yi-Zhun Zhu*

Abstract:

A new synthetic method of leonurine was developed. Leonurine 1 was synthesized from the key intermediates 4 and 5, two compounds with high solubility in dichloromethane which allowed the synthetic procedure to be performed under mild conditions and afforded 1 with a good yield. Comparing the previous methods, the yield was increased from 30% to 54%, time consumed was significantly reduced as well.

Key words: Leonurine, Motherwort, Cardioprotective agent

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