Novel inhibitors for p90 ribosomal S6 protein kinase 2: design, synthesis and SAR

doi:10.5246/jcps.2012.05.053

Abstract

Abstract:

A series of benzohydrazide derivatives as novel ribosomal S6 kinase 2 (RSK2) inhibitors were designed and synthesized from a hit compound previously discovered by ligand-based virtual screening. Biological assays showed that these compounds possessed moderate inhibitory activities towards RSK2. The structural activity relationships (SAR) were elucidated by molecular docking and further optimization was performed.

Key words: RSK2 inhibitors, Benzohydrazide derivatives, SAR, Molecular docking

CLC Number:

R916

Supporting:

Mengzhu Xue, Jun Yuan, Bin Wu, Xue Zhao, Xiaofeng Liu, Jin Huang, Zhenjiang Zhao^*, Honglin Li^*, Yufang Xu. Novel inhibitors for p90 ribosomal S6 protein kinase 2: design, synthesis and SAR[J]. , DOI: 10.5246/jcps.2012.05.053.

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