Preparation and characterization of budesonide-loaded solid lipid nanoparticles for pulmonary delivery

doi:10.5246/jcps.2011.04.049

Abstract

Abstract:

To increase the solubility and adsorption of budesonide (BUD), budesonide-loaded solid lipid nanoparticles (BUD-SLNs) were prepared and characterized in this study. Glycerin monostearate (GMS) was selected to be the matrix lipid material after calculation the differences of partial solubility parameters. An emulsification-ultrasound diffusion method was employed and formula was optimized in the BUD-SLNs preparation. The entrapment efficiency (ee%) of BUD-SLNs was (97.77±2.60)%, and the mean particle size was 147.3 nm (PDI = 0.228). Uniform and sphere particles were observed under TEM. The in vitro release of BUD-SLNs could be well explained by the biphasic release dynamics equation. The spectrums of DSC and X-ray diffraction indicated that BUD molecules were dispersed mainly into the lipids to form homogeneous matrix structure. Our results provide fundamental data for the application of SLNs in pulmonary delivery system.

Key words: Budesonide, Solid lipid nanoparticles, Pulmonary drug delivery, Preparation, Characterization

CLC Number:

R943.4

Supporting:

Pei-Ran Zhang, Ying-Feng Tu, Shuo Wang, Yi-Hui Wang, Ying Xie^*, Miao Li^*, Yi-Guang Jin. Preparation and characterization of budesonide-loaded solid lipid nanoparticles for pulmonary delivery [J]. , DOI: 10.5246/jcps.2011.04.049.

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Preparation and characterization of budesonide-loaded solid lipid nanoparticles for pulmonary delivery

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