Abstract:

The incidence and mortality of cancer have been increasing alarmingly in China and worldwide^[1]. Unlike other chronic diseases such as metabolic, cardiovascular, and neuropathies, most cancers, especially metastatic ones, are still essentially uncontrollable in spite of significant progresses such as early diagnosis and immunotherapies. Fortunately, human cancer generally takes about 10–30 years to develop; hence there is a window of opportunity to prevent cancer before it becoming metastatic and radio/chemotherapeutic resistant. Indeed, prevention has made huge contribution to cancer control in the United States and some European countries, and chemoprevention is one of the most attractive strategies.

Key words: Cancers chemoprevention, Dietary phytochemicals, Traditional Chinese medicines, Epigenetics, Cellular signaling pathways