Bioassay-based dissolution test of Shuanghuanglian tablet

doi:10.5246/jcps.2011.01.011

• Full Papers • Previous Articles Next Articles

Bioassay-based dissolution test of Shuanghuanglian tablet

Long Xiao, Jin Han, Xue Huang, Yuan-Yuan Zhang, Hai-Long Yuan^*, Xiao-He Xiao

1. Military Institute of Chinese Medicine, 302 Military Hospital, Beijing 100039, China
2. Department of Pharmacy, 302 Military Hospital, Beijing 100039, China

Received:2010-09-21 Revised:2010-11-15 Online:2011-01-15 Published:2011-01-15
Contact: Hai-Long Yuan*

Abstract

Abstract:

It has been difficult to perform dissolution test on solid preparations of traditional Chinese medicines (TCMs). TCMs are different from chemical drugs in that their chemical compositions are complicated. The measurement method based on chemical approach alone is incomplete. In order to solve this problem, in this study a bioassay-based dissolution test was developed. Microcalorimetry was used to obtain growth power-time curves and biothermodynamic parameters of Staphylococcus aureus inhibited by the solution of ShuangHuangLian (SHL) tablet, which was dissolved in phosphate buffer (pH 6.8) for different times. The results of the bioassay-based dissolution test of SHL tablet demonstrated that the bioassay method might be a promising alternative for its quality control.

Key words: Dissolution test, Shuanghuanglian tablet, Bioassay, Traditional Chinese medicines

CLC Number:

R927.11

Supporting:

Long Xiao, Jin Han, Xue Huang, Yuan-Yuan Zhang, Hai-Long Yuan^*, Xiao-He Xiao . Bioassay-based dissolution test of Shuanghuanglian tablet[J]. , DOI: 10.5246/jcps.2011.01.011.

[1]	Ah-Ng Tony Kong, Siwang Yu. Cancers chemoprevention by dietary phytochemicals and traditional Chinese medicines: epigenetics and cellular signaling pathways [J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(4): 233-234.
[2]	Ping Chen, Peipei Wang, Guohua Shao, Lan Xiang^*. Acetylcholinesterase inhibitory activities of 48 traditional Chinese medicinal herbs [J]. , 2013, 22(1): 106-109.
[3]	Long Cui^*, Zhi Li, Ya-Nan Sun, Nan Zhang, Young-Ho Kim. Inhibition of protein tyrosine phosphatase 1B activity by triterpenes isolated from Aceriphyllum rossii [J]. , 2012, 21(2): 178-182.
[4]	Xing-Xin Yang, Yan-Li Zhang, Xiao-Xia Zhang, Xiao-Ni Li^*. Cell membrane chromatography and its application in the analysis of bioactive ingredients of TCMs [J]. , 2011, 20(1): 20-25.
[5]	Dong-Mei Su, Hui-Lin Zhao^, Huan-Zhang Xia . In vivo* bioassay to determine the potency of a new erythropoiesis stimulating protein [J]. , 2010, 19(1): 43-46.
[6]	Tang Haifeng, Zhao Yueping, Jiang Yongpei, Wang Zhongzhuang, Yi Yanghua, Lei Qiyun. Triterpenoid Saponins from Eclipta prostrata L. [J]. , 2001, 10(4): 183-186.
[7]	Pei-Pei Zhang, Hua-Xin Yang, Kang-Sen Xu, Zhan-Jun Li, An-Zhuang Yan. Studies on the Quality of Recombinant Human Growth Hormone [J]. , 1996, 5(1): 20-27.

Bioassay-based dissolution test of Shuanghuanglian tablet

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 7

Recommended Articles

Metrics

Comments