Selection of characteristic spectral bands for the analysis by the NIR correlation coefficient method

doi:10.5246/jcps.2011.01.012

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Selection of characteristic spectral bands for the analysis by the NIR correlation coefficient method

Ting Liu, Yan-Chun Feng, Dan-Qing Song, Chang-Qin Hu^*

1. Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China
2. National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050, China

Received:2010-09-09 Revised:2010-11-10 Online:2011-01-15 Published:2011-01-15
Contact: Chang-Qin Hu*

Abstract

Abstract:

We analyzed the infrared (IR)-near infrared (NIR) 2D correlation spectra of drugs perturbed by temperature. By identification of functional groups by IR spectrum and by the correlation analysis of IR-NIR spectrum, we identified the characteristic spectral bands that were closely related to the structure of a drug substance of interest. These characteristic spectral bands were relatively less interfered by other ingredients for analysis by the NIR correlation coefficient method. With these characteristic spectral bands, the accuracy of screening illegally added Sildenafil citrate, Tadalafil and Metformin hydrochloride in Chinese patent drugs and healthcare products reached about 90%, which met the requirements of rapid screening.

Key words: Two-dimensional correlation spectroscopy, NIR, Correlation coefficient method by characteristic spectral bands, Chinese patent drug, Illegal additive

CLC Number:

R917

Supporting:

Ting Liu, Yan-Chun Feng, Dan-Qing Song, Chang-Qin Hu^* . Selection of characteristic spectral bands for the analysis by the NIR correlation coefficient method[J]. , DOI: 10.5246/jcps.2011.01.012.

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Selection of characteristic spectral bands for the analysis by the NIR correlation coefficient method

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