Impact of clinical pharmacist intervention on rational use of surgical antibiotic prophylaxis in thyroid surgery

doi:10.5246/jcps.2015.09.078

Journal of Chinese Pharmaceutical Sciences ›› 2015, Vol. 24 ›› Issue (9): 617-624.DOI: 10.5246/jcps.2015.09.078

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Impact of clinical pharmacist intervention on rational use of surgical antibiotic prophylaxis in thyroid surgery

Yuanchao Zhu^1*, Yongfang Hu^2,3*, Liping Yang¹, Xin Hu¹

1. Department of Pharmacy, Beijing Hospital, Assessment of Clinical Drugs Risk and Individual Application Key Laboratory, Beijing 100730, China
2. Department of Pharmacy, Beijing Tsinghua Chang Gung Hospital, Beijing 102218, China
3. Department of Pharmacy, Peking University Third Hospitail, Beijing 100191, China

Received:2015-05-14 Revised:2015-05-28 Online:2015-09-18 Published:2015-06-25
Contact: Tel.: 86-10-85133637, 13718106819, 13811172632, E-mail: yczhu-2009@163.com, hhyx66@163.com

Abstract

Abstract:

In the present study, we aimed to evaluate the intervention effect of prophylactic antibiotic use in thyroid surgery in a largehospital. From 2004 to 2012, 70 patients who underwent thyroid surgery were randomly selected each year. The quality of surgical antibiotic prophylaxis (SAP) was assessed each year in terms of antibiotic ratio, choice, duration, timing, combination, route of administration and so on. The result showed that the SAP ratio was 100% from 2004 to 2010. With our intervention, this SAP ratio was decreased to 45.7% in 2011, and it reached 2.9% in 2012. The AUD was consistently greater than 38 before 2010, while it rapidly declined to 1 in 2012. The number of DDDs per 100 operations was decreased from 431 to 3 after the intervention. The average cost of antibiotic drugs per patient was RMB 350.65 in 2010, whereas it was decreased to RMB 18.51 in 2012. The average duration of hospitalization showed no difference during the intervention. This study indicated that implementation of a multi-disciplinary protocol and clinical pharmacist interventions could improve the rational use of SAP.

Key words: Thyroid surgery, Clinical pharmacist, Surgical antibiotic prophylaxis, DDDs, AUD

CLC Number:

R969.3

Supporting:

Yuanchao Zhu, Yongfang Hu, Liping Yang, Xin Hu. Impact of clinical pharmacist intervention on rational use of surgical antibiotic prophylaxis in thyroid surgery[J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(9): 617-624.

References

[1] Shojania, K.G.; Duncan, B.W.; McDonald, K.M. Evid. Rep. Technol. Assess (Summ). 2001, 43, i-x, 1-668.

[2] Khan, A.K.A.; Rashed, M.R. J. Clin. Diagn. Res. 2013, 7, 671-674.

[3] Ozgun, H.; Ertugrul, B.M.; Soyder, A. Int. J. Surg. 2010, 8, 159-163.

[4] Ou, Y.; Jing, B.Q.; Guo, F.F. Am. J. Infect. Control. 2014, 42, 516-520.

[5] Bratzler, D.W.; Houck, P.M. Clin. Infect. Dis. 2004, 38, 1706-1715.

[6] Dale, W.B.; Patchen, D.; Keith, M.O. Am. J. Health. Syst. Pharm. 2013, 70, 195-283.

[7] Scottish Intercollegiate Guidelines Network. This article can be found online at http://www.sign.ac.uk/guidelines/fulltext/104/index.html

[8] Li, Y. B. M. J. 2014, 348, g1083.

[9] The Ministry of Health. Nat. Med. J. China. 2004, 84, 1857-1862.

[10] Surgery Branch of the Chinese Medical Association. Chin. J. Surg. 2006, 44, 1594-1596.

[11] Department of Medical Administration, Ministry of Health of the PRC. This article can be found online at http://www.moh.gov.cn/mohbgt/s9508/200903/39723.shtml

[12] Department of Medical Administration, Ministry of Health of the PRC. This article can be found online at http://www.moh.gov.cn/mohyzs/s3586/201104/51376.shtml

[13] Akalin, S.; Kutlu, S.S.; Cirak, B. Int. J. Clin. Pharm. 2012, 34, 120-126.

[14] Alerany, C.; Campany, D.; Monterde, J. J. Hosp. Infect. 2005, 60, 111-117.

[15] Sun, J. J. Evid. Based. Med. 2013, 6, 126-135.

[16] Zhang, H.X.; Li, X.; Huo, H.Q. PLoS. One. 2014, 9, e88971.

[17] WHO, Collaborating Center for Drug Statistics Methodology. This article can be found online at http://www.whocc.no/ atcddd/

[18] Anderson, D.J.; Kaye, K.S.; Classen, D. Infect. Control. Hosp. Epidemiol. 2008, 29, S51-61.

[19] van Kasteren, M.E.E.; Kullberg, B.J.; deBoer, A.S. J. Antimicrob. Chemother. 2003, 51, 1389-1396.

[20] Gomez, M.I.; Acosta-Gnass, S.I.; Mosqueda-Barboza, L. Infect. Control. Hosp. Epidemiol. , 27, 1358-1365.2006

[21] Tang, Y.; Chen, X.; Li, Y. Chin. J. Infect. Control. 2008, 7, 255-258.

[22] Bao, L.; Ren, X.; Wang, Y. Afri. J. Pharm. Pharmacol. 2011, 5, 2062-2066.

[23] Hard, R.G.; Forsythe, I.L. Thyroid. 2007, 17, 63-65.

[24] Bailly, P.; Lallemand, S.; Thouverez, M. J. Hosp. Infect. 2001, 49, 135-138.

[25] Hou, F.Q.; Sun, X.T.; Shen, B.Q. J. Chin. Pharm. Sci. 2002, 11, 51-54.

Impact of clinical pharmacist intervention on rational use of surgical antibiotic prophylaxis in thyroid surgery

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