In vitro studies on the multi-target anti-Alzheimer activities of berberine-like alkaloids from Coptidis Rhizoma

doi:10.5246/jcps.2014.06.052

Journal of Chinese Pharmaceutical Sciences ›› 2014, Vol. 23 ›› Issue (6): 385-392.DOI: 10.5246/jcps.2014.06.052

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In vitro studies on the multi-target anti-Alzheimer activities of berberine-like alkaloids from Coptidis Rhizoma

Ying Hu¹, Yanfang Yang¹, Wenzhi Yang², Yingtao Zhang^1*

1. School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
2. Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

Received:2014-03-29 Revised:2014-05-09 Online:2014-06-28 Published:2014-05-15
Contact: Tel.: 86-10-82801559

Abstract

Abstract:

Coptidis Rhizoma, a well known heat-clearing Chinese Materia Medica, exhibited multi-target anti-Alzheimer effects in vitro through inhibition of Aβ42 aggregation, AChE, and BACE1. Six berberine-like alkaloids were found to be the major active constituents of Coptidis Rhizoma by HPLC analysis along with activity assays. A standard combination of the six major alkaloids was demonstrated to fully reproduce the in vitroeffects of Coptidis Rhizoma. Molecular docking studies revealed that berberine-like alkaloids could directly bind at the active sites of Aβ42, AChE, and BACE1 through hydrophobic interactions, aromatic stacking, and electrostatic interactions.

Key words: Coptidis Rhizoma, Alzheimer’s disease, Amyloid β, AChE, BACE1

CLC Number:

R284

Supporting:

Ying Hu, Yanfang Yang, Wenzhi Yang, Yingtao Zhang. In vitro studies on the multi-target anti-Alzheimer activities of berberine-like alkaloids from Coptidis Rhizoma[J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(6): 385-392.

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In vitro studies on the multi-target anti-Alzheimer activities of berberine-like alkaloids from Coptidis Rhizoma

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