A perspective on picornavirus inhibitors and concrete evolution of WIN compounds

doi:10.5246/jcps.2012.06.066

Abstract

Abstract: The family Picornaviridae is one of the largest families of human viral pathogens, causing an extensive range of clinical manifestations from mild fever, common cold to serious paralytic poliomyelitis, COPD, etc., some of which can even be life-threatening. Picornaviruses also cause zoonotic epidemics that result in dramatic social and economical losses. Although no efficient antivirus agent for prophylaxis or treatment of picornarivus infections has been officially approved yet, a large number of anti-picornavirus compounds with potent activity have been developed and investigated, through which further information about picornavirus has been revealed as well. Viral mRNA translation, viral mRNA replication and especially the viral capsid are the three main targets of these compounds having been extensively studied. The typical one is the WIN series of compounds that bind to the viral capsid and inhibit rival attachment or uncoating. Herein, a perspective on picornavirus inhibitors and a concrete evolution of WIN compounds will be presented in this paper.

Key words: Picornavirus, Antiviral agent, Capsid binding inhibitor, WIN compound, Pleconaril

CLC Number:

R916

Supporting:

Long Ren, Ning Jiao^*. A perspective on picornavirus inhibitors and concrete evolution of WIN compounds[J]. , DOI: 10.5246/jcps.2012.06.066.

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