Modification of oligonucleotides by isonucleosides incorporation and peptides conjugation

doi:10.5246/jcps.2012.06.065

Abstract

Abstract:

Synthetic oligonucleotides including antisense oligonucleotides and siRNA have shown promising therapeutic potential. However, to realize the therapeutic potential of synthetic oligonucleotides, many obstacles have to be overcome, such as their poor biological stability, non-specific activity and inadequate cell membrane permeability. In this paper, the achievements by Lihe Zhang's group in the study of isonucleotide modified oligonucleotides and oligonucleotides conjugated with cell penetrating peptides are summarized.

Key words: Synthetic oligonucleotide, Isonucleoside, Cell penetrating peptide, siRNA

CLC Number:

R916.1

Supporting:

Ye Huang, Xiaofeng Wang, Zhenjun Yang^*, Lihe Zhang . Modification of oligonucleotides by isonucleosides incorporation and peptides conjugation[J]. , DOI: 10.5246/jcps.2012.06.065.

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