Design and synthesis of L-5'-noraristeromycin analogues as potent antitumor agents

Abstract

Abstract:

Nucleoside analogues show a variety of biological activities. To prepare new purine nucleoside analogues that could inhibit the proliferation of tumor cells and resist enzyme hydrolysis, we designed and synthesized 15 different L-5'-noraristeromycin analogues, in which thioether, sulfoxide or sulfone function was introduced to replace the 5'-hydroxymethyl group. Their anti-tumor activities were assayed in vitro. One compound showed potent anti-tumor activity.

Key words: Carbocyclic nucleoside, L-Nucleoside analogue, Antitumor

CLC Number:

R916.4

Supporting:

Min-Jun Huang, Zhen-Jun Yang, Liang-Ren Zhang^*, Li-He Zhang . Design and synthesis of L-5'-noraristeromycin analogues as potent antitumor agents [J]. .

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