Abstract: The purpose of this study was to evaluate the pharmacokinetic parameters and bioavailability of the solid dispersion formulation of diclazuril after oral administration in rabbits in comparison with its known premix form with feed additive. Plasma concentrations were determined by high-performance liquid chromatography (HPLC). The areas under the plasma concentration curves (AUC0–∞) of diclazuril in solid dispersion and premix were 247.8±18.1 μg/h/mL and 145.4±12.6 μg/h/mL, respectively. The Cmax of diclazuril in solid dispersion and premix were 33.72±4.75 μg/mL and 16.42±3.48 μg/mL, respectively. The t1/2 were 9.53±1.37 and 9.23±1.20 min, respectively. The oral bioavailability of drug solid dispersion was 1.7-fold higher than that of premix. From these data we concluded that diclazuril solid dispersion may be used as a potential anticoccidial preparation.

Key words: Diclazuril, Diclazuril, Rabbits, Rabbits, Pharmacokinetics, Pharmacokinetics, Oral administration, Oral administration, High-performance liquid chromatography, High-performance liquid chromatography