Cell penetrating peptides and their applications in siRNA delivery

Abstract

Abstract:

Given its ability to knock down essentially any gene of interest, siRNA has been one of the promising candidates for gene therapy. However, like other nucleic-acid-based drugs, its poor cellular uptake poses a major challenge. Here we briefly summarize the use of cell penetrating peptides (CPPs) as a novel and promising approach for siRNA delivery. The main advantages of CPPs are their low toxicity and high efficiency.

Key words:

siRNA,

siRNA, Cell penetrating peptides, Cell penetrating peptides, Delivery

, Delivery

CLC Number:

R916

Supporting:

Xiao-Feng Wang, Yang Liu, Zhuo Wang, Zhen-Jun Yang^*, Li-He Zhang. Cell penetrating peptides and their applications in siRNA delivery[J]. .

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