Antioxidant phenanthrenes and lignans from Dendrobium nobile

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Antioxidant phenanthrenes and lignans from Dendrobium nobile

Xue Zhang, Jie-Kun Xu, Nai-Li Wang, Hiroshi Kurihara, Xin-Sheng Yao^*

1. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;
2. Key Laboratory for Research and Development of New Drugs from Traditional Chinese Medicine and
Natural Products in Shenzhen, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, China;
3. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China

Received:2008-06-22 Revised:2008-11-15 Online:2008-12-15 Published:2008-12-15
Contact: Xin-Sheng Yao

Abstract

Abstract:

To study the antioxidant constituents from the stems of Dendrobium nobile, and to discuss their structure-activity relationship. Compounds were isolated from a 60% ethanolic extract by various chromatographic techniques and were identified by spectral analysis. The antioxidant activities of compounds were evaluated by DPPH free radical scavenging assay. Five phenanthrenes and four lignans were obtained from the active fractions of D. nobile. Their structures were identified as fimbriatone (1), confusarin (2), flavanthrinin (3), 2,5-dihydroxy-4,9-dimethoxyphenanthrene (4), 3,7-dihydroxy-2,4-dimethoxyphenanthrene (5), syringaresinol (6), pinoresinol (7), medioresinol (8) and lirioresinol-A (9), respectively. Compounds 2 and 6 exhibited more potent DPPH scavenging activities than vitamin C. All the above compounds were reported from this plant for the first time, and compounds 3, 4 and 9 were reported for the first time from the genus of Dendrobium. For all phenanthrenes and lignans, an electron-donating methoxyl group in the ortho position to the phenolic hydroxyl group exhibits enhanced antioxidant activities.

Key words: Dendrobium nobile, Dendrobium nobile, Phenanthrenes, Phenanthrenes, Lignans, Lignans, Antioxidant activity, Antioxidant activity, DPPH free radical scavenging assay, DPPH free radical scavenging assay, Structure-activity relationship, Structure-activity relationship, ,

Supporting:

Xue Zhang, Jie-Kun Xu, Nai-Li Wang, Hiroshi Kurihara, Xin-Sheng Yao^*
. Antioxidant phenanthrenes and lignans from Dendrobium nobile
[J]. .

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