Abstract:

To investigate the metabolites of baicalein 6,7-diacetate in rats. HPLC-DAD and LC/MSn methods were used to analyze the metabolites in intestinal tract and plasma after oral administration of baicalein 6,7-diacetate to rats. Baicalein 6,7-diacetate was degraded into baicalein 6-monoacetate and baicalein in rat intestinal tract, and four baicalein glucuronides, baicalein 6-O-glucuronide, baicalein 6-methoxyl-7-O-glucuronide, baicalein 6,7-di-O-glucuronide, and baicalein 6-O-glucose-7-O-glucuronide were detected and tentatively identified in rat plasma. This is the first time to report the metabolites of baicalein 6,7-diacetate in rats. Six metabolites were identified in rat intestinal tract and plasma.

Key words: Baicalein 6,7-diacetate, Baicalein 6,7-diacetate, Baicalein, Baicalein, Metabolites, Metabolites, ,