Abstract:

Aim To establish a HPLC method for the separation of the enantiomers of zolmitriptan. Methods The separations were performed on Chiralcel OJ column with hexane-ethanol-diethylamine (85:15:0.2) as mobile phase at a flow rate of 0.8 mL·min^-1 and detecttion wavelength of 227 nm at 35 ºC. Several related parameters for separation were studied. Results Baseline separation (Rs>1.5) was easily obtained in the case, and the R-isomer impurity in zolmitriptan was determined. Conclusion The method developed in this study has been successfully applied for quality-control purposes.

Key words: enantioseparation, enantioseparation, zolmitriptan, zolmitriptan, HPLC, HPLC, chiral stationary phases, chiral stationary phases