Anticancer Activities of Substituted Cinnamic Acid Phenethyl Esters on Human Cancer Cell Lines

Abstract

Abstract: Caffeic acid phenethyl ester (CAPE) and sixteen substituted cinnamic acid phenethyl esters were prepared via conventional procedures in order to test their in vitro anticancer activities by either MTT assay or SRB assay on six different human cancer cell lines. The results indicated that in the concentration of 10 μmol·L-1 the lead compound CAPE possessed anticancer activities against human HL-60, Bel-7402, and Hela cell lines, and two other compounds possessed potent anticancer activities against Bel-7402 and Hela cell lines.

Key words: medicinal chemistry, medicinal chemistry, cinnamic acid phenethyl esters, cinnamic acid phenethyl esters, chemical synthesis, chemical synthesis, anticancer activity, anticancer activity

CLC Number:

R916.41

R979.1

Supporting:

LI Shu-chun, LI Hui, ZHANG Fa, LI Zhong-jun^*, CUI Jing-rong^*^*. Anticancer Activities of Substituted Cinnamic Acid Phenethyl Esters on Human Cancer Cell Lines[J]. .

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