Synthesis of Aminoglucose Conjugates of 5-Fluorouracil-1-acetic Acid and 5-Fluorouracil-1-propanoic Acid and Their Antitumor Activities

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Synthesis of Aminoglucose Conjugates of 5-Fluorouracil-1-acetic Acid and 5-Fluorouracil-1-propanoic Acid and Their Antitumor Activities

Zuo Daishu, Jiang Tao^*, Guan Huashi, Qin Xin, Tian Quan, Liu Fulong

Marine Drug and Food Institute, Ocean University of Qingdao, 266003

Received:2001-02-20 Revised:2001-08-27 Online:2001-12-15 Published:2001-12-15
Contact: Jiang Tao*

Abstract

Abstract: Six aminoglucose conjugates were synthesized by the reaction of aminoglucose with 5-fluorou-racil-1-acetic acid or 5-fluorouracil-1-propanoic acid and confirmed by IR, ¹H NMR and elemental analyses. Their antitumor activities against A2780 cells and PC-14 cells were also evaluated.

Key words: Aminoglucose and its derivatives, Aminoglucose and its derivatives, 5-Fluorouracil, 5-Fluorouracil, Antitumor activities, Antitumor activities

Supporting:

Zuo Daishu, Jiang Tao^*, Guan Huashi, Qin Xin, Tian Quan, Liu Fulong . Synthesis of Aminoglucose Conjugates of 5-Fluorouracil-1-acetic Acid and 5-Fluorouracil-1-propanoic Acid and Their Antitumor Activities[J]. .

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Synthesis of Aminoglucose Conjugates of 5-Fluorouracil-1-acetic Acid and 5-Fluorouracil-1-propanoic Acid and Their Antitumor Activities

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