Abstract: The SOD-like activities of copper salicylate encapsulated in neutral, positively and negatively charged liposomes were studied with cytochrome c method. The results showed that the SOD-like activity of copper salicylate encapsulated in neutral liposomes was enhanced over 3 times more than that of copper salicylate in aqueous solution. However, the activity decreased for copper salicylate encapsulated in positively and negatively charged liposomes. It was also found that at experimental concentrations there was no regularity for the change of activity of copper salicylate encapsulated in negatively charged liposomes, and copper salicylate encapsulated in liposomes with more negative charges could promote the dismutation of superoxide anion free radicals, however, so could copper salicylate encapsulated in liposomes with fewer negative charges only in lower concentrations.

Key words: Superoxide radical, SOD-like activity, Liposome, Copper complex