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Syntheses and Pharmacological Activity of Some 17-[(2'-Substituted)-4'-pyrimidyl]androstene Derivatives As Inhibitors of Human 17α-Hydroxylase/C17,20-Layse

Ru Chengjie, Lei Xiaoping, Ling Yangzhi*, Zhang Lihe, Venkatech Hundratta, Angela Brodie   

  1. 1. School of Pharmaceutical Sciences, Peking University, Beijing 100083;
    2. Department of Pharmacology & Experimental Therapeutics, School of Medicine, University of Maryland, Baltimore, USA 21201
  • Received:2000-10-09 Revised:2000-12-25 Online:2001-03-15 Published:2001-03-15
  • Contact: Ling Yangzhi*

Abstract: A new compound, desmosdumotin A (1), was isolated from the roots of Desmos dumosus (Roxb.)Saff. Its chemical structure was established as 5-hydroxy-7-methoxy-8-formyl-3-benzoyl-2,6-dimethyl-2R,3S-dihydrochromone on the basis of spectral methods, including 1H-1H COSY, 1H-13C COSY, and HMBC as well as singlecrystal X-ray analysis.

Key words: Benign prostatic hypertrophy, BPH, Prostatic cancer, 17-Pyrimidylandrostenes, P45017α inhibitors

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