Abstract: Ugi-4CC(four-component condensation) reaction is one of isonitrile-based MCR’s (multi-component reactions), which is started with an amine, an aldehyde, a carboxylic acid and an isocyanide, after one-pot reaction to produce a compound composed of the whole four starting materials. The reaction makes full use of the specialty of isonitrile and can be used to build a series of compounds with different structural skeletons by using diverse inputs. In our work, two kinds of isonitriles were synthesized and a parallel synthesis of an α-acylamino amide library was performed to modify the Ugi reaction conditions.

Key words: MCR's multi-component reactions, Isonitrile, Ugi-4CC reaction, Condensation condition