Abstract: A series of 2-(E)-(4-hydroxy-3-methoxybenzylidene)-5-(N-substituted ami-nomethyl) cyclopentanones was synthesized and evaluated for the anti-inflammatory activity. All of the target compounds were confirmed by spectral analysis and elemental analysis. Preliminary pharmacological tests showed that several compounds exerted appreciable inhibitory effect on xylene-induced ear edema in mice and that alteration of the substituents of anilines had significant influence in anti-inflammatory potency.

Key words: Cyclopentanone derivative, Mannich base, Amine exchange reaction, Anti-inflammatory activity