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Synthesis and Antitumor Activity of Podophyllotoxin Analogues

Kuan-Ke Lu, Fan-Ming Liu, Yao-Zu Chen*   

  1. 1. Institute of Applied Pharmaceutical Research, School of Pharmaceutical Science, Beijing Medical University, 100083;
    2. The State Key Laboratory of Applied Organic Chemistry, Lanzhou University, 730000
  • Received:1997-11-20 Revised:1998-04-24 Online:1998-12-15 Published:1998-12-15
  • Contact: Yao-Zu Chen*

Abstract: Seven podophyllotoxin analogues were synthesized by condensation of 4’-demethyl epipodophyllotoxin 10 with 5-alkyl-4-amino-3-mercapto-1,2,4-triazoles 9(a-g) in the presence of TFA(CF3COOH). Their antitumor activities were screened in vitro against HL-60 and K562 cells.

Key words: Podophyllotoxin, Antitumor activity, 1,2,4-Triazoles

Supporting: