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Synthesis of 2-(AlkyIthio)-1,2,4-triazolo[1,5-a]pyrimidines and 3-(Alkythio)-1,2,4-triazolo[3,4-a] pyrimidines and Their Vasodilator Activity

Tian-Rui Ren*, Fu-Heng Chen, Jia-Ju Zhou, Hong-Ming Chen, Zong-Ru Guo   

  1. 1. Department of Applied Chemistry, China A gricultural University, Beijing 100094;
    2. Laboratory of Computer Chemistry, Institute of Chemical Metallurgy, Chinese Academy of Sciences, Beijing 100080;
    3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050

  • Received:1997-06-12 Revised:1997-12-09 Online:1998-12-15 Published:1998-12-15
  • Contact: Tian-Rui Ren*

Abstract: A series of new 2-(alkylthio)-5,7-dimethyl-l,2,4-triazolo[1,5-a] pyrimidines and 3-(alkylthio)-5,7-dimethyl-1,2,4-triazolo[3,4-a] pyrimidines have been synthesized. These derivatives were evaluated for inhibitory effects on 85.7 mmol·L-1 K+ and 10-4 mol·L-1 NE(nor-epinephrine)- induced contraction ofrat aorta strips.

Key words: Triazolopyrimidine, Vasodilator activity, Synthesis

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