Tumor Necrosis Factor Production in Mouse Macrophages and its Pharmacological Modulation by Ganoderma lucidum

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Tumor Necrosis Factor Production in Mouse Macrophages and its Pharmacological Modulation by Ganoderma lucidum

Yong-Feng Jia, Hong Li, Masao Mori, Luo-Xiu Zhang

1. Department of Pharmacology, School of Pharmacy, Shanghai Medical University, Shanghai 200032;
2. Wakan Shoyaku Botany Institute, Tokyo, Japan

Received:1996-10-21 Revised:1997-09-16 Online:1998-03-15 Published:1998-03-15

Abstract

Abstract: Effects of Ganoderma lucidum (GL) on the cytotoxic activity of tumor necrosis factor (TNF) or its production were examined using murine fibroblast cell line (L929 cells). It was found that GL 1~100 μg/mL had no direct influence on the growth of L929 cells, and GL showed less synergistic activity on the cytotoxicity of rTNF. However, GL 0.01~10 μg/mL promoted TNF production by macrophages in vitro. Preincubated with GL for 8 h before LPS, macrophages produced higher TNF activity in vitro. Besides, GL 100~300 mg/kg po qd×14 enhanced the level of TNF in the serum of mice primed by BCG and induced by endotoxin.

Key words: Ganoderma lucidum, Tumor necrosis factor, Macrophage

Supporting:

Yong-Feng Jia, Hong Li, Masao Mori, Luo-Xiu Zhang. Tumor Necrosis Factor Production in Mouse Macrophages and its Pharmacological Modulation by Ganoderma lucidum[J]. .

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Tumor Necrosis Factor Production in Mouse Macrophages and its Pharmacological Modulation by Ganoderma lucidum

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