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Inhibitory Actions of Berbamine on Delayed-type Hypersensitivity in Mice

Xin Lin, Chong-Nian Luo, Pu Feng, Shu-Xiang Liu, Li-Wei Wang, Shu-Sheng Xie, Pei-Gen Xiao   

  1. 1. Department of Immunology, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094;
    2. Research Center for Immunology, Beijing Medical University, Beijing 100083
  • Received:1996-11-08 Revised:1997-10-10 Online:1998-03-15 Published:1998-03-15

Abstract: The action of berbamine on murine delayed-type hypersensitivity (DTH) reaction induced by sheep red blood cells (SRBC), 2,4-dinitrochlorobenzene, and allotypic splenocytes was studied. The results show that berbamine can inhibit the DTH reaction significantly. It is concluded that berbamine may inhibit cell mediated immunity in mice.

Key words: Berbamine, Delayed-type hypersensitivity, Cell mediated immunity, Mice

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