Water Soluble Active Components of Salvia miltiorrhiza and Related Plants

Abstract

Abstract: Chemical studies on nine Salvia species yielded various polyphenolic acids. Eleven of them were depsides of R-(+)-β-(3,4-dihydroxyphenyl) lactic acid and a caffeic acid derivative or caffeic acid dimer. Except the two known depsides, rosmarinic acid and lithospermic acid, this type of depsides has not been isolated from other plant materials before, so they were named salvianolic acid A, B, C, D, E, H, I, J and isosalvianolic acid C. Salvianolic acid F, G and przewalskinic acid A were new polyphenolic acids. Pharmacological studies of these polyphenolic acids showed potent antioxidant activities. The effects of these components in protecting against brain and heart damage have been studied.

Key words: Salvia miltiorrhiza, Depsides, Salvianolic acid, Antioxidant, Biological activities

Supporting:

Lian-Niang Li. Water Soluble Active Components of Salvia miltiorrhiza and Related Plants[J]. .

References

[1] Huang SL. Botany of Salvia miltiorrhiza.. In: Xu RS. ed. Danshen-Biology and Its A pplication.. Beijing: Science Press, 1990, 23-25.
[2] Li LN, Tan R, Chen WM. Planta Med, 1984, 50: 227.
[3] Ai CB, Li LN. J Nat Prod, 1988, 51: 145.
[4] Ai CB, Li LN. Planta Med, 1992, 58: 197.
[5] Ai CB, Li LN. Chinese Chem Lett, 1996, 7: 427.
[6] Ai CB, Li LN. Chinese Chem Lett, 1991, 2: 17.
[7] Zhang HJ, Li LN. Chinese Chem Lett, 1993, 4: 501.
[8] Zhang HJ, Li LN. Planta Med, 1994, 60: 70.
[9] Ai CB, Deng QH, Song WZ, Li LN, Phytochemistry, 1994, 37: 907.
[10] Qian TX, Li LN. Phytochemistry, 1992, 31: 1068.
[11] Li J, Li LN, Song WZ. Chinese Traditional and Herbal Drugs, 1994, 24: 347.
[12] Lu XZ, Xu WH, Shen JX, Naoki H. Chinese Chem Lett 1991, 2: 301.
[13] Zhao LM, He WY, Liang XT, Li LN. Chinese Chem Lett, 1996,7: 449.
[14] Zhao LM, Liang XT, Li LN. Phytochemistry, 1996, 42: 899.
[15] Qian TX, Yan ZH, Li LN. J Chin Pharm Sci, 1993, 2: 148.
[16] Gottlieb OR. Phytochemistry, 1972, 11: 1537.
[17] Liu GT, Zhang TM, Wang BE, Wang YW. Biochem Pharmacol, 1992, 42: 147.
[18] Xu LN, Li DY, Tian JY. Proc. 3rd. Nat Symp of Activating Blood Circulation and Removing Stasis Research: Oct. 1990, Lushan, p198.
[19] Lin TJ, Liu GT. Chin J Pharmacol Toxicol, 1991, 5: 276.
[20] Lin TJ, Liu GT, Liu Y, Xu GZ. Free Radical Biology & Medicine, 1992, 12: 347.
[21] Zou ZW, Xu LN, Tian JY. Acta Pharm Sin, 1993, 28: 241.
[22] Yu WG, Xu LN. Acta Pharm Sin, 1994, 29: 412.
[23] Du GH, Qiu Y, Zhang JT. Acta Pharm Sin, 1995, 30: 731.
[24] Du GH, Zhang JT. Acta Pharm Sin, 1995, 30: 184.
[25] Du GH, Qiu Y, Tian YE, Zhang J T. Acta Pharm Sin, 1995, 30: 561.
[26] Murakami S, Kijima H, Isobe Y, Muramatsu M., Aihara H, Otomo S, Li LN, Ai CB. Planta Med, 1990, 56: 360.
[27] Tanaka T, Morimoto S, Nonaka G, Nishioka I, Yokozawa T, Chung HY, Oura H, Chem Pharm Bull, 1989, 37: 340.
[28] Kohda H, Takeda O, Tanaka S, Yamasaki K, Yamashita A, Kurokawa T, Ishibashi S. Chem Pharm Bull, 1989, 37: 1287.