The role of Helicobacter pylori infection in gastric carcinogenesis and its prevention by using Chinese medicinal herbs

doi:10.5246/jcps.2016.04.029

Abstract

Abstract:

As the fifth most common cancer and the third most common cause of cancer deaths worldwide, gastric cancer remains a significant public health concern and an economic burden in developed and developing countries. Gastric inflammation induced by Helicobacter pylori may initiate superficial gastritis, which then progresses to atrophic gastritis, gastric epithelial dysplasia, and finally gastric cancer. The pathogenesis of H. pylori infection is related to its virulence factors, including urease, flagella, vacuolating cytotoxin A and cytotoxin-associated gene antigen. The relevant mechanisms of H. pylori-induced inflammation include activation of nuclear factor-κB, mitogen-activated protein kinase pathway, and oxidative stress. To date, therapeutic strategies and results in this infection remain undesirable. Complicated treatment issues include antibiotic resistance, adverse effects of chemical drugs, and recurrence after operation. Therefore, chemoprevention has been regarded as an important measure, and Chinese medicinal herbs have been the research hotspot. This review aimed to summarize the effects of Chinese medicinal herbs on the prevention of gastric cancer, mechanism of action and the treatment prospects, with emphasis H. pylori-induced effects.

Key words: Gastric cancer, H. pylori, Virulence factors, Inflammation, Medicinal plants, Chemoprevention

CLC Number:

R962

Supporting:

Fangyuan Li, Guiyu Zhang, Rilan Ou, Ying Wang, Xiaoxiao Qi, Zhongqiu Liu, Linlin Lu. The role of Helicobacter pylori infection in gastric carcinogenesis and its prevention by using Chinese medicinal herbs[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(4): 250-265.

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