Advances of bacterial transferase MraY and its inhibitors

doi:10.5246/jcps.2015.03.017

Journal of Chinese Pharmaceutical Sciences ›› 2015, Vol. 24 ›› Issue (3): 137-147.DOI: 10.5246/jcps.2015.03.017

Advances of bacterial transferase MraY and its inhibitors

Yuanyuan Jin^1#, Juanjuan Liu^1,2#, Xiaozhou Feng¹, Yadong Li^1,2, Wan Sun¹, Kangyou Wang^1,2, Xifeng Tian^2*, Zhaoyong Yang^1*

1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Hebei United University, Tangshan 063000, China

Received:2014-11-05 Revised:2014-12-03 Online:2015-03-29 Published:2014-12-16
Contact: Tel.: 86-10-63165283
About author:Dr. Yang graduated from Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences in 2003 and obtained his Ph.D. degree. During 2008–2011, he did postdoctoral research at University of Kentucky. In December 2011, he joined the Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences as a Professor. His research interest is the identification of enzyme with novel catalytic mechanism in the natural product biosynthesis pathway, and to be applied in practice, in order to complete the enzymatic synthesis of pharmaceutical intermediates of significance.
Supported by:
National Natural Science Foundation of China (Grant No. 81273414 and Grant No. 81321004), NSFC-NIH International Cooperation and Exchange Programs (Grant No. 81261120417, 2012-2013).

Abstract

Abstract:

The phospho-murNAc-pentapeptide translocase (MraY, translocase I) is a good target for the development of new antibiotics as it is ubiquitous and essential for bacterial growth. Furthermore, several inhibitors targeting towards this enzyme have been discovered. Recently, the crystal structure of MraY has been presented by Chung et al. Combination of the crystal structure and structure-activity relationship studies on these inhibitors could lead to the identification of active pharmacophores, and insight into their mechanisms of action. In this review, we described the structure and inhibitors of MraY. In addition, we also discussed the structure-activity relationship of these inhibitors and prospects of MraY as an antibacterial target.

Key words: Peptidoglycan, MraY, Antibiotic, Structure-activity relationships

CLC Number:

R962

Supporting:

Yuanyuan Jin, Juanjuan Liu, Xiaozhou Feng, Yadong Li, Wan Sun, Kangyou Wang, Xifeng Tian, Zhaoyong Yang. Advances of bacterial transferase MraY and its inhibitors[J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(3): 137-147.

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Advances of bacterial transferase MraY and its inhibitors

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